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Offline svenach

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Offline alexender

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To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid gland secretions of the toad, [/size]Incilius alvarius[/size]. Several synthetic routes were initially explored, and the selected process featured an optimized Fischer indole reaction to 5-MeO-DMT freebase in high yield, from which the 1:1 succinate salt was produced to provide 136 g of crystalline active pharmaceutical ingredient (API) with 99.86% peak area by high-performance liquid chromatography (HPLC) and a net yield of 49%. The report contains information on in-process monitoring, validated analytical methods, impurity formation and removal, and solid-state characterization of the APIā€”all essential for further clinical development.

 

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